Grupa A
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | Manchester City FC | 6 | 4 | 0 | 2 | 18 | 10 | 8 | 12 |
| 2 | PSG | 6 | 3 | 2 | 1 | 13 | 8 | 5 | 11 |
| 3 | RB Leipzig | 6 | 2 | 1 | 3 | 15 | 14 | 1 | 7 |
| 4 | Club Brugge KV | 6 | 1 | 1 | 4 | 6 | 20 | -14 | 4 |
Meciuri
15.09.2021, 22:00
Manchester City FC – RB Leipzig
6 – 3
15.09.2021, 22:00
Club Brugge KV – PSG
1 – 1
28.09.2021, 22:00
PSG – Manchester City FC
2 – 0
28.09.2021, 22:00
RB Leipzig – Club Brugge KV
1 – 2
19.10.2021, 19:45
Club Brugge KV – Manchester City FC
1 – 5
19.10.2021, 22:00
PSG – RB Leipzig
3 – 2
3.11.2021, 22:00
RB Leipzig – PSG
2 – 2
3.11.2021, 22:00
Manchester City FC – Club Brugge KV
4 – 1
24.11.2021, 22:00
Manchester City FC – PSG
2 – 1
24.11.2021, 22:00
Club Brugge KV – RB Leipzig
0 – 5
7.12.2021, 19:45
RB Leipzig – Manchester City FC
2 – 1
7.12.2021, 19:45
PSG – Club Brugge KV
4 – 1
Grupa B
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | Liverpool FC | 6 | 6 | 0 | 0 | 17 | 6 | 11 | 18 |
| 2 | Atlético Madrid | 6 | 2 | 1 | 3 | 7 | 8 | -1 | 7 |
| 3 | FC Porto | 6 | 1 | 2 | 3 | 4 | 11 | -7 | 5 |
| 4 | AC Milan | 6 | 1 | 1 | 4 | 6 | 9 | -3 | 4 |
Meciuri
15.09.2021, 22:00
Atlético Madrid – FC Porto
0 – 0
15.09.2021, 22:00
Liverpool FC – AC Milan
3 – 2
28.09.2021, 22:00
FC Porto – Liverpool FC
1 – 5
28.09.2021, 22:00
AC Milan – Atlético Madrid
1 – 2
19.10.2021, 22:00
Atlético Madrid – Liverpool FC
2 – 3
19.10.2021, 22:00
FC Porto – AC Milan
1 – 0
3.11.2021, 19:45
AC Milan – FC Porto
1 – 1
3.11.2021, 22:00
Liverpool FC – Atlético Madrid
2 – 0
24.11.2021, 22:00
Liverpool FC – FC Porto
2 – 0
24.11.2021, 22:00
Atlético Madrid – AC Milan
0 – 1
7.12.2021, 22:00
FC Porto – Atlético Madrid
1 – 3
7.12.2021, 22:00
AC Milan – Liverpool FC
1 – 2
Grupa C
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | AFC Ajax | 6 | 6 | 0 | 0 | 20 | 5 | 15 | 18 |
| 2 | Sporting CP | 6 | 3 | 0 | 3 | 14 | 12 | 2 | 9 |
| 3 | Borussia Dortmund | 6 | 3 | 0 | 3 | 10 | 11 | -1 | 9 |
| 4 | Beşiktaş JK | 6 | 0 | 0 | 6 | 3 | 19 | -16 | 0 |
Meciuri
15.09.2021, 19:45
Beşiktaş JK – Borussia Dortmund
1 – 2
15.09.2021, 22:00
Sporting CP – AFC Ajax
1 – 5
28.09.2021, 19:45
AFC Ajax – Beşiktaş JK
2 – 0
28.09.2021, 22:00
Borussia Dortmund – Sporting CP
1 – 0
19.10.2021, 19:45
Beşiktaş JK – Sporting CP
1 – 4
19.10.2021, 22:00
AFC Ajax – Borussia Dortmund
4 – 0
3.11.2021, 22:00
Borussia Dortmund – AFC Ajax
1 – 3
3.11.2021, 22:00
Sporting CP – Beşiktaş JK
4 – 0
24.11.2021, 19:45
Beşiktaş JK – AFC Ajax
1 – 2
24.11.2021, 22:00
Sporting CP – Borussia Dortmund
3 – 1
7.12.2021, 22:00
AFC Ajax – Sporting CP
4 – 2
7.12.2021, 22:00
Borussia Dortmund – Beşiktaş JK
5 – 0
Grupa D
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | Real Madrid | 6 | 5 | 0 | 1 | 14 | 3 | 11 | 15 |
| 2 | FC Internazionale Milano | 6 | 3 | 1 | 2 | 8 | 5 | 3 | 10 |
| 3 | FC Sheriff | 6 | 2 | 1 | 3 | 7 | 11 | -4 | 7 |
| 4 | FC Shakhtar Donetsk | 6 | 0 | 2 | 4 | 2 | 12 | -10 | 2 |
Meciuri
15.09.2021, 19:45
FC Sheriff – FC Shakhtar Donetsk
2 – 0
15.09.2021, 22:00
FC Internazionale Milano – Real Madrid
0 – 1
28.09.2021, 19:45
FC Shakhtar Donetsk – FC Internazionale Milano
0 – 0
28.09.2021, 22:00
Real Madrid – FC Sheriff
1 – 2
19.10.2021, 22:00
FC Shakhtar Donetsk – Real Madrid
0 – 5
19.10.2021, 22:00
FC Internazionale Milano – FC Sheriff
3 – 1
3.11.2021, 19:45
Real Madrid – FC Shakhtar Donetsk
2 – 1
3.11.2021, 22:00
FC Sheriff – FC Internazionale Milano
1 – 3
24.11.2021, 19:45
FC Internazionale Milano – FC Shakhtar Donetsk
2 – 0
24.11.2021, 22:00
FC Sheriff – Real Madrid
0 – 3
7.12.2021, 22:00
Real Madrid – FC Internazionale Milano
2 – 0
7.12.2021, 22:00
FC Shakhtar Donetsk – FC Sheriff
1 – 1
Grupa E
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | FC Bayern München | 6 | 6 | 0 | 0 | 22 | 3 | 19 | 18 |
| 2 | SL Benfica | 6 | 2 | 2 | 2 | 7 | 9 | -2 | 8 |
| 3 | FC Barcelona | 6 | 2 | 1 | 3 | 2 | 9 | -7 | 7 |
| 4 | FC Dinamo Kiev | 6 | 0 | 1 | 5 | 1 | 11 | -10 | 1 |
Meciuri
14.09.2021, 22:00
FC Barcelona – FC Bayern München
0 – 3
14.09.2021, 22:00
FC Dinamo Kiev – SL Benfica
0 – 0
29.09.2021, 22:00
SL Benfica – FC Barcelona
3 – 0
29.09.2021, 22:00
FC Bayern München – FC Dinamo Kiev
5 – 0
20.10.2021, 19:45
FC Barcelona – FC Dinamo Kiev
1 – 0
20.10.2021, 22:00
SL Benfica – FC Bayern München
0 – 4
2.11.2021, 22:00
FC Bayern München – SL Benfica
5 – 2
2.11.2021, 22:00
FC Dinamo Kiev – FC Barcelona
0 – 1
23.11.2021, 19:45
FC Dinamo Kiev – FC Bayern München
1 – 2
23.11.2021, 22:00
FC Barcelona – SL Benfica
0 – 0
8.12.2021, 22:00
FC Bayern München – FC Barcelona
3 – 0
8.12.2021, 22:00
SL Benfica – FC Dinamo Kiev
2 – 0
Grupa F
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | Manchester United FC | 6 | 3 | 2 | 1 | 11 | 8 | 3 | 11 |
| 2 | Villarreal CF | 6 | 3 | 1 | 2 | 12 | 9 | 3 | 10 |
| 3 | Atalanta BC | 6 | 1 | 3 | 2 | 12 | 13 | -1 | 6 |
| 4 | BSC Young Boys | 6 | 1 | 2 | 3 | 7 | 12 | -5 | 5 |
Meciuri
14.09.2021, 19:45
BSC Young Boys – Manchester United FC
2 – 1
14.09.2021, 22:00
Villarreal CF – Atalanta BC
2 – 2
29.09.2021, 19:45
Atalanta BC – BSC Young Boys
1 – 0
29.09.2021, 22:00
Manchester United FC – Villarreal CF
2 – 1
20.10.2021, 22:00
Manchester United FC – Atalanta BC
3 – 2
20.10.2021, 22:00
BSC Young Boys – Villarreal CF
1 – 4
2.11.2021, 22:00
Atalanta BC – Manchester United FC
2 – 2
2.11.2021, 22:00
Villarreal CF – BSC Young Boys
2 – 0
23.11.2021, 19:45
Villarreal CF – Manchester United FC
0 – 2
23.11.2021, 22:00
BSC Young Boys – Atalanta BC
3 – 3
8.12.2021, 22:00
Manchester United FC – BSC Young Boys
1 – 1
9.12.2021, 20:00
Atalanta BC – Villarreal CF
2 – 3
Grupa G
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | LOSC Lille | 6 | 3 | 2 | 1 | 7 | 4 | 3 | 11 |
| 2 | FC Red Bull Salzburg | 6 | 3 | 1 | 2 | 8 | 6 | 2 | 10 |
| 3 | Sevilla FC | 6 | 1 | 3 | 2 | 5 | 5 | 0 | 6 |
| 4 | VfL Wolfsburg | 6 | 1 | 2 | 3 | 5 | 10 | -5 | 5 |
Meciuri
14.09.19:45
Sevilla FC – FC Red Bull Salzburg
1 – 1
14.09.2021, 22:00
LOSC Lille – VfL Wolfsburg
0 – 0
29.09.2021, 22:00
FC Red Bull Salzburg – LOSC Lille
2 – 1
29.09.2021, 22:00
VfL Wolfsburg – Sevilla FC
1 – 1
20.10.2021, 19:45
FC Red Bull Salzburg – VfL Wolfsburg
3 – 1
20.10.2021, 22:00
LOSC Lille – Sevilla FC
0 – 0
2.11.2021, 19:45
VfL Wolfsburg – FC Red Bull Salzburg
2 – 1
2.11.2021, 22:00
Sevilla FC – LOSC Lille
1 – 2
23.11.2021, 22:00
LOSC Lille – FC Red Bull Salzburg
1 – 0
23.11.2021, 22:00
Sevilla FC – VfL Wolfsburg
2 – 0
8.12.2021, 22:00
FC Red Bull Salzburg – Sevilla FC
1 – 0
8.12.2021, 22:00
VfL Wolfsburg – LOSC Lille
1 – 3
Grupa H
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | Juventus FC | 6 | 5 | 0 | 1 | 10 | 6 | 4 | 15 |
| 2 | Chelsea FC | 6 | 4 | 1 | 1 | 13 | 4 | 9 | 13 |
| 3 | FC Zenit | 6 | 1 | 2 | 3 | 10 | 10 | 0 | 5 |
| 4 | Malmö FF | 6 | 0 | 1 | 5 | 1 | 14 | -13 | 1 |
Meciuri
14.09.2021, 22:00
Chelsea FC – FC Zenit
1 – 0
14.09.2021, 22:00
Malmö FF – Juventus FC
0 – 3
29.09.2021, 19:45
FC Zenit – Malmö FF
4 – 0
29.09.2021, 22:00
Juventus FC – Chelsea FC
1 – 0
20.10.2021, 22:00
FC Zenit – Juventus FC
0 – 1
20.10.2021, 22:00
Chelsea FC – Malmö FF
4 – 0
2.11.2021, 19:45
Malmö FF – Chelsea FC
0 – 1
2.11.2021. 22:00
Juventus FC – FC Zenit
4 – 2
23.11.2021, 22:00
Chelsea FC – Juventus FC
4 – 0
23.11.2021, 22:00
Malmö FF – FC Zenit
1 – 1
8.12.2021, 19:45
FC Zenit – Chelsea FC
3 – 3
8.12.2021, 19:45
Juventus FC – Malmö FF
1 – 0