Grupa A
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | LASK Linz | 6 | 5 | 1 | 0 | 12 | 1 | 11 | 16 |
| 2 | Maccabi Tel Aviv | 6 | 3 | 2 | 1 | 14 | 4 | 10 | 11 |
| 3 | HJK Helsinki | 6 | 2 | 0 | 4 | 5 | 15 | -10 | 6 |
| 4 | FC Alashkert | 6 | 0 | 1 | 5 | 4 | 15 | -11 | 1 |
Meciuri
14.09.2021, 17:30
Maccabi Tel Aviv – FC Alashkert
4 – 1
16.09.2021, 19:45
HJK Helsinki – LASK Linz
0 – 2
30.09.2021, 19:45
FC Alashkert – HJK Helsinki
2 – 4
30.09.2021, 19:45
LASK Linz – Maccabi Tel Aviv
1 – 1
21.10.2021, 17:30
HJK Helsinki – Maccabi Tel Aviv
0 – 5
21.10.2021, 19:45
FC Alashkert – LASK Linz
0 – 3
4.11.2021, 19:45
Maccabi Tel Aviv – HJK Helsinki
3 – 0
4.11.2021, 19:45
LASK Linz – FC Alashkert
2 – 0
25.11.2021, 19:45
HJK Helsinki – FC Alashkert
1 – 0
25.11.2021, 22:00
Maccabi Tel Aviv – LASK Linz
0 – 1
9.12.2021, 19:45
LASK Linz – HJK Helsinki
3 – 0
9.12.2021, 19:45
FC Alashkert – Maccabi Tel Aviv
1 – 1
Grupa B
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | KAA Gent | 6 | 4 | 1 | 1 | 6 | 2 | 4 | 13 |
| 2 | FK Partizan | 6 | 2 | 2 | 2 | 6 | 4 | 2 | 8 |
| 3 | Anorthosis Famagusta FC | 6 | 1 | 3 | 2 | 6 | 9 | -3 | 6 |
| 4 | FC Flora | 6 | 1 | 2 | 3 | 5 | 8 | -3 | 5 |
Meciuri
16.09.2021, 19:45
FC Flora – KAA Gent
0 – 1
16.09.2022, 22:00
Anorthosis Famagusta FC – FK Partizan
0 – 2
30.09.2021, 19:45
FK Partizan – FC Flora
2 – 0
30.09.2021, 19:45
KAA Gent – Anorthosis Famagusta FC
2 – 0
21.10.2021, 19:45
Anorthosis Famagusta FC – FC Flora
2 – 2
21.10.2021, 22:00
FK Partizan – KAA Gent
0 – 1
4.11.2021, 17:30
FC Flora – Anorthosis Famagusta FC
2 – 2
4.11.2021, 19:45
KAA Gent – FK Partizan
1 – 1
25.11.2021, 17:30
FC Flora – FK Partizan
1 – 0
25.11.2021, 22:00
Anorthosis Famagusta FC – KAA Gent
1 – 0
9.12.2021, 19:45
KAA Gent – FC Flora
1 – 0
9.12.2021, 19:45
FK Partizan – Anorthosis Famagusta FC
1 – 1
Grupa C
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | AS Roma | 6 | 4 | 1 | 1 | 18 | 11 | 7 | 13 |
| 2 | FK Bodø/Glimt | 6 | 3 | 3 | 0 | 14 | 5 | 9 | 12 |
| 3 | FC Zorya Luhansk | 6 | 2 | 1 | 3 | 5 | 11 | -6 | 7 |
| 4 | PFC CSKA Sofia | 6 | 0 | 1 | 5 | 3 | 13 | -10 | 1 |
Meciuri
16.09.2021, 22:00
FK Bodø/Glimt – FC Zorya Luhansk
3 – 1
16.09.2021, 22:00
AS Roma – PFC CSKA Sofia
5 – 1
30.09.2021, 19:45
PFC CSKA Sofia – FK Bodø/Glimt
0 – 0
30.09.2021, 19:45
FC Zorya Luhansk – AS Roma
0 – 3
21.10.2021, 19:45
FK Bodø/Glimt – AS Roma
6 – 1
21.10.2021, 22:00
PFC CSKA Sofia – FC Zorya Luhansk
0 – 1
4.11.2021, 19:45
FC Zorya Luhansk – PFC CSKA Sofia
2 – 0
4.11.2021, 22:00
AS Roma – FK Bodø/Glimt
2 – 2
25.11.2021, 22:00
AS Roma – FC Zorya Luhansk
4 – 0
25.11.2021, 22:00
FK Bodø/Glimt – PFC CSKA Sofia
2 – 0
9.12.2021, 19:45
PFC CSKA Sofia – AS Roma
2 – 3
9.12.2021, 19:45
FC Zorya Luhansk – FK Bodø/Glimt
1 – 1
Grupa D
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | AZ Alkmaar | 6 | 4 | 2 | 0 | 8 | 3 | 5 | 14 |
| 2 | Randers FC | 6 | 1 | 4 | 1 | 9 | 9 | 0 | 7 |
| 3 | FK Jablonec | 6 | 1 | 3 | 2 | 6 | 8 | -2 | 6 |
| 4 | CFR Cluj | 6 | 1 | 1 | 4 | 4 | 7 | -3 | 4 |
Meciuri
16.09.2021, 22:00
Randers FC – AZ Alkmaar
2 – 2
16.09.2021, 22:00
FK Jablonec – CFR Cluj
1 – 0
30.09.2021, 19:45
CFR Cluj – Randers FC
1 – 1
30.09.2021, 19:45
AZ Alkmaar – FK Jablonec
1 – 0
21.10.2021, 22:00
CFR Cluj – AZ Alkmaar
0 – 1
21.10.2021, 22:00
FK Jablonec – Randers FC
2 – 2
4.11.2021, 19:45
Randers FC – FK Jablonec
2 – 2
4.11.2021, 19:45
AZ Alkmaar – CFR Cluj
2 – 0
25.11.2021, 22:00
Randers FC – CFR Cluj
2 – 1
25.11.2021, 22:00
FK Jablonec – AZ Alkmaar
1 – 1
9.12.2021, 19:45
CFR Cluj – FK Jablonec
2 – 0
9.12.2021, 19:45
AZ Alkmaar – Randers FC
1 – 0
Grupa E
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | Feyenoord Rotterdam | 6 | 4 | 2 | 0 | 11 | 6 | 5 | 14 |
| 2 | SK Slavia Praga | 6 | 2 | 2 | 2 | 8 | 7 | 1 | 8 |
| 3 | 1. FC Union Berlin | 6 | 2 | 1 | 3 | 8 | 9 | -1 | 7 |
| 4 | Maccabi Haifa | 6 | 1 | 1 | 4 | 2 | 7 | -5 | 4 |
Meciuri
14.09.2021, 17:30
Maccabi Haifa – Feyenoord Rotterdam
0 – 0
16.09.2021, 19:45
SK Slavia Praga – 1. FC Union Berlin
3 – 1
30.09.2021, 22:00
1. FC Union Berlin – Maccabi Haifa
3 – 0
30.09.2021, 22:00
Feyenoord Rotterdam – SK Slavia Praga
2 – 1
21.10.2021, 19:45
Feyenoord Rotterdam – 1. FC Union Berlin
3 – 1
21.10.2021, 19:45
Maccabi Haifa – SK Slavia Praga
1 – 0
4.11.2021, 22:00
1. FC Union Berlin – Feyenoord Rotterdam
1 – 2
4.11.2021, 22:00
SK Slavia Praga – Maccabi Haifa
1 – 0
25.11.2021, 19:45
SK Slavia Praga – Feyenoord Rotterdam
2 – 2
25.11.2021, 19:45
Maccabi Haifa – 1. FC Union Berlin
0 – 1
9.12.2021, 22:00
1. FC Union Berlin – SK Slavia Praga
1 – 1
9.12.2021, 22:00
Feyenoord Rotterdam – Maccabi Haifa
2 – 1
Grupa F
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | FC Copenhaga | 6 | 5 | 0 | 1 | 15 | 5 | 10 | 15 |
| 2 | PAOK Salonic | 6 | 3 | 2 | 1 | 8 | 4 | 4 | 11 |
| 3 | ŠK Slovan Bratislava | 6 | 2 | 2 | 2 | 8 | 7 | 1 | 8 |
| 4 | Lincoln Red Imps FC | 6 | 0 | 0 | 6 | 2 | 17 | -15 | 0 |
Meciuri
16.09.2021, 19:45
Lincoln Red Imps FC – ŠK Slovan Bratislava
0 – 2
16.09.2021, 19:45
ŠK Slovan Bratislava – FC Copenhaga
1 – 3
30.09.2021, 22:00
PAOK Salonic – ŠK Slovan Bratislava
1 – 1
30.09.2021, 22:00
FC Copenhaga – Lincoln Red Imps FC
3 – 1
21.10.2021, 19:45
FC Copenhaga – PAOK Salonic
1 – 2
21.10.2021, 22:00
ŠK Slovan Bratislava – Lincoln Red Imps FC
2 – 0
4.11.2021, 19:45
Lincoln Red Imps FC – ŠK Slovan Bratislava
1 – 4
4.11.2021, 22:00
PAOK Salonic – FC Copenhaga
1 – 2
25.11.2021, 19:45
Lincoln Red Imps FC – FC Copenhaga
0 – 4
25.11.2021, 19:45
ŠK Slovan Bratislava – PAOK Salonic
0 – 0
9.12.2021, 22:00
FC Copenhaga – ŠK Slovan Bratislava
2 – 0
9.12.2021, 22:00
PAOK Salonic – Lincoln Red Imps FC
2 – 0
Grupa G
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | Stade Rennais FC | 6 | 4 | 2 | 0 | 13 | 7 | 6 | 14 |
| 2 | SBV Vitesse | 6 | 3 | 1 | 2 | 12 | 9 | 3 | 10 |
| 3 | Tottenham Hotspur FC | 6 | 2 | 1 | 3 | 11 | 11 | 0 | 7 |
| 4 | NŠ Mura | 6 | 1 | 0 | 5 | 5 | 14 | -9 | 3 |
Meciuri
16.09.2021, 19:45
NŠ Mura – SBV Vitesse
0 – 2
16.09.2021, 19:45
Stade Rennais FC – Tottenham Hotspur FC
2 – 2
30.09.2021, 22:00
SBV Vitesse – Stade Rennais FC
1 – 2
30.09.2021, 22:00
Tottenham Hotspur FC – NŠ Mura
5 – 1
21.10.2021, 19:45
SBV Vitesse – Tottenham Hotspur FC
1 – 0
21.10.2021, 19:45
NŠ Mura – Stade Rennais FC
1 – 2
4.11.2021, 22:00
Tottenham Hotspur FC – SBV Vitesse
3 – 2
4.11.2021, 22:00
Stade Rennais FC – NŠ Mura
1 – 0
25.11.2021, 19:45
SNŠ Mura – Tottenham Hotspur FC
2 – 1
25.11.2021, 19:45
Stade Rennais FC – SBV Vitesse
3 – 3
9.12.2021, 22:00
SBV Vitesse – NŠ Mura
3 – 1
Grupa H
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | FC Basel | 6 | 4 | 2 | 0 | 14 | 6 | 8 | 14 |
| 2 | FK Qarabağ | 6 | 3 | 2 | 1 | 10 | 8 | 2 | 11 |
| 3 | AC Omonia Nicosia | 6 | 0 | 4 | 2 | 5 | 10 | -5 | 4 |
| 4 | FC Kairat | 6 | 0 | 2 | 4 | 6 | 11 | -5 | 2 |
Meciuri
16.09.2021, 17:30
FC Kairat – AC Omonia Nicosia
0 – 0
16.09.2021, 19:45
FK Qarabağ – FC Basel
0 – 0
30.09.2021, 22:00
AC Omonia Nicosia – FK Qarabağ
1 – 4
30.09.2021, 22:00
FC Basel – FC Kairat
4 – 2
21.10.2021, 19:45
FK Qarabağ – FC Kairat
2 – 1
21.10.2021, 22:00
FC Basel – AC Omonia Nicosia
3 – 1
4.11.2021, 17:30
FC Kairat – FK Qarabağ
1 – 2
4.11.2021, 19:45
AC Omonia Nicosia – FC Basel
1 – 1
25.11.2021, 17:30
FC Kairat – FC Basel
2 – 3
25.11.2021, 19:45
FK Qarabağ – AC Omonia Nicosia
2 – 2
9.12.2021, 22:00
AC Omonia Nicosia – FC Kairat
0 – 0
9.12.2021, 22:00
FC Basel – FK Qarabağ
3 – 0