Grupa A
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | Olympique Lyon | 6 | 5 | 1 | 0 | 16 | 5 | 11 | 16 |
| 2 | Rangers FC | 6 | 2 | 2 | 2 | 6 | 5 | 1 | 8 |
| 3 | AC Sparta Praga | 6 | 2 | 1 | 3 | 6 | 9 | -3 | 7 |
| 4 | Brøndby IF | 6 | 0 | 2 | 4 | 2 | 11 | -9 | 2 |
Meciuri
16.09.2021, 22:00
Brøndby IF – AC Sparta Praga
0 – 0
16.09.2021, 22:00
Rangers FC – Olympique Lyon
0 – 2
30.09.2021, 19:45
Olympique Lyon – Brøndby IF
3 – 0
30.09.2021, 19:45
AC Sparta Praga – Rangers FC
1 – 0
21.10.2021, 22:00
Rangers FC – Brøndby IF
2 – 0
21.10.2021, 22:00
AC Sparta Praga – Olympique Lyon
3 – 4
4.11.2021, 19:45
Brøndby IF – Rangers FC
1 – 1
4.11.2021, 19:45
Olympique Lyon – AC Sparta Praga
3 – 0
25.11.2021, 22:00
Brøndby IF – Olympique Lyon
1 – 3
25.11.2021, 22:00
Rangers FC – AC Sparta Praga
2 – 0
9.12.2021, 19:45
AC Sparta Praga – Brøndby IF
2 – 0
9.12.2021, 19:45
Olympique Lyon – Rangers FC
1 – 1
Grupa B
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | AS Monaco FC | 6 | 3 | 3 | 0 | 7 | 4 | 3 | 12 |
| 2 | Real Sociedad | 6 | 2 | 3 | 1 | 9 | 6 | 3 | 9 |
| 3 | PSV Eindhoven | 6 | 2 | 2 | 2 | 9 | 8 | 1 | 8 |
| 4 | SK Sturm Graz | 6 | 0 | 2 | 4 | 3 | 10 | -7 | 2 |
Meciuri
16.09.2021, 22:00
AS Monaco FC – SK Sturm Graz
1 – 0
16.09.2021, 22:00
PSV Eindhoven – Real Sociedad
2 – 2
30.09.2021, 19:45
Real Sociedad – AS Monaco FC
1 – 1
30.09.2021, 19:45
SK Sturm Graz – PSV Eindhoven
1 – 4
21.10.2021, 22:00
PSV Eindhoven – AS Monaco FC
1 – 2
21.10.2021, 22:00
SK Sturm Graz – Real Sociedad
0 – 1
4.11.2021, 19:45
AS Monaco FC – PSV Eindhoven
0 – 0
4.11.2021, 19:45
Real Sociedad – SK Sturm Graz
1 – 1
25.11.2021, 22:00
AS Monaco FC – Real Sociedad
2 – 1
25.11.2021, 22:00
PSV Eindhoven – SK Sturm Graz
2 – 0
9.12.2021, 19:45
SK Sturm Graz – AS Monaco FC
1 – 1
9.12.2021, 19:45
Real Sociedad – PSV Eindhoven
3 – 0
Grupa C
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | FC Spartak Moscova | 6 | 3 | 1 | 2 | 10 | 9 | 1 | 10 |
| 2 | SSC Napoli | 6 | 3 | 1 | 2 | 15 | 10 | 5 | 10 |
| 3 | Leicester City FC | 6 | 2 | 2 | 2 | 12 | 11 | 1 | 8 |
| 4 | Legia Varșovia | 6 | 2 | 0 | 4 | 4 | 11 | -7 | 6 |
Meciuri
15.09.2021, 17:30
FC Spartak Moscova – Legia Varșovia
0 – 1
16.09.2021, 22:00
Leicester City FC – SSC Napoli
2 – 2
30.09.2021, 19:45
Legia Varșovia – Leicester City FC
1 – 0
30.09.2021, 19:45
SSC Napoli – FC Spartak Moscova
2 – 3
20.10.2021, 17:30
FC Spartak Moscova – Leicester City FC
3 – 4
21.10.2021, 22:00
SSC Napoli – Legia Varșovia
3 – 0
4.11.2021, 19:45
Legia Varșovia – SSC Napoli
1 – 4
4.11.2021, 22:00
Leicester City FC – FC Spartak Moscova
1 – 1
24.11.2021, 17:30
FC Spartak Moscova – SSC Napoli
2 – 1
25.11.2021, 22:00
Leicester City FC – Legia Varșovia
3 – 1
9.12.2021, 19:45
Legia Varșovia – FC Spartak Moscova
0 – 1
9.12.2021, 19:45
SSC Napoli – Leicester City FC
3 – 2
Grupa D
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | Eintracht Frankfurt | 6 | 3 | 3 | 0 | 10 | 6 | 4 | 12 |
| 2 | Olympiacos FC | 6 | 3 | 0 | 3 | 8 | 7 | 1 | 9 |
| 3 | Fenerbahçe SK | 6 | 1 | 3 | 2 | 7 | 8 | -1 | 6 |
| 4 | Royal Antwerp FC | 6 | 1 | 2 | 3 | 6 | 10 | -4 | 5 |
Meciuri
16.09.2021, 22:00
Eintracht Frankfurt – Fenerbahçe SK
1 – 1
16.09.2021, 22:00
Olympiacos FC – Royal Antwerp FC
2 – 1
30.09.2021, 19:45
Royal Antwerp FC – Eintracht Frankfurt
0 – 1
30.09.2021, 19:45
Fenerbahçe SK – Olympiacos FC
0 – 3
21.10.2021, 19:45
Fenerbahçe SK – Royal Antwerp FC
2 – 2
21.10.2021, 22:00
Eintracht Frankfurt – Olympiacos FC
3 – 1
4.11.2021, 19:45
Olympiacos FC – Eintracht Frankfurt
1 – 2
4.11.2021, 22:00
Royal Antwerp FC – Fenerbahçe SK
0 – 3
25.11.2021, 22:00
Eintracht Frankfurt – Royal Antwerp FC
2 – 2
25.11.2021, 22:00
Olympiacos FC – Fenerbahçe SK
1 – 0
9.12.2021, 19:45
Fenerbahçe SK – Eintracht Frankfurt
1 – 1
9.12.2021, 19:45
Royal Antwerp FC – Olympiacos FC
1 – 0
Grupa E
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | Galatasaray SK | 6 | 3 | 3 | 0 | 7 | 3 | 4 | 12 |
| 2 | SS Lazio | 6 | 2 | 3 | 1 | 7 | 3 | 4 | 9 |
| 3 | Olympique de Marseille | 6 | 1 | 4 | 1 | 6 | 7 | -1 | 7 |
| 4 | FC Lokomotiv Moscova | 6 | 0 | 2 | 4 | 2 | 9 | -7 | 2 |
Meciuri
16.09.2021, 19:45
Galatasaray SK – SS Lazio
1 – 0
16.09.2021, 19:45
FC Lokomotiv Moscova – Olympique de Marseille
1 – 1
30.09.2021, 22:00
Olympique de Marseille – Galatasaray SK
0 – 0
30.09.2021, 22:00
SS Lazio – FC Lokomotiv Moscova
2 – 0
21.10.2022, 19:45
SS Lazio – Olympique de Marseille
0 – 0
21.10.2022. 22:00
FC Lokomotiv Moscova – Galatasaray SK
0 – 1
4.11.2022, 19:45
Galatasaray SK – FC Lokomotiv Moscova
1 – 1
4.11.2021, 22:00
Olympique de Marseille – SS Lazio
2 – 2
25.11.2021, 19:45
Galatasaray SK – Olympique de Marseille
4 – 2
25.11.2021, 19:45
FC Lokomotiv Moscova – SS Lazio
0 – 3
9.12.2021, 22:00
SS Lazio – Galatasaray SK
0 – 0
9.12.2021, 22:00
Olympique de Marseille – FC Lokomotiv Moscova
1 – 0
Grupa F
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | Steaua Roșie Belgrad | 6 | 3 | 2 | 1 | 6 | 4 | 2 | 11 |
| 2 | SC Braga | 6 | 3 | 1 | 2 | 12 | 9 | 3 | 10 |
| 3 | FC Midtjylland | 6 | 2 | 3 | 1 | 7 | 7 | 0 | 9 |
| 4 | PFK Ludogoreț Razgrad | 6 | 0 | 2 | 4 | 3 | 8 | -5 | 2 |
Meciuri
16.09.2021, 19:45
Steaua Roșie Belgrad – SC Braga
2 – 1
16.09.2021, 19:45
FC Midtjylland – PFK Ludogoreț Razgrad
1 – 1
30.09.2021, 22:00
PFK Ludogoreț Razgrad – Steaua Roșie Belgrad
0 – 1
30.09.2021, 22:00
SC Braga – FC Midtjylland
3 – 1
21.10.2021, 19:45
FC Midtjylland – Steaua Roșie Belgrad
1 – 1
21.10.2021, 19:45
PFK Ludogoreț Razgrad – SC Braga
0 – 1
4.11.2021, 22:00
Steaua Roșie Belgrad – FC Midtjylland
0 – 1
4.11.2021, 22:00
SC Braga – PFK Ludogoreț Razgrad
4 – 2
25.11.2021, 19:45
Steaua Roșie Belgrad – PFK Ludogoreț Razgrad
1 – 0
25.11.2021, 19:45
FC Midtjylland – SC Braga
3 – 2
9.12.2021, 22:00
SC Braga – Steaua Roșie Belgrad
1 – 1
9.12.2021, 22:00
PFK Ludogoreț Razgrad – FC Midtjylland
0 – 0
Grupa G
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | Bayer 04 Leverkusen | 6 | 4 | 1 | 1 | 14 | 5 | 9 | 13 |
| 2 | Real Betis | 6 | 3 | 1 | 2 | 12 | 12 | 0 | 10 |
| 3 | Celtic FC | 6 | 3 | 0 | 3 | 13 | 15 | -2 | 9 |
| 4 | Ferencváros TC | 6 | 1 | 0 | 5 | 5 | 12 | -7 | 3 |
Meciuri
16.09.2021, 19:45
Bayer 04 Leverkusen – Ferencváros TC
2 – 1
16.09.2021, 19:45
Real Betis – Celtic FC
4 – 3
30.09.2021, 22:00
Celtic FC – Bayer 04 Leverkusen
0 – 4
30.09.2021, 22:00
Ferencváros TC – Real Betis
1 – 3
19.10.2021, 17:30
Celtic FC – Ferencváros TC
2 – 0
21.10.2021, 19:45
Real Betis – Bayer 04 Leverkusen
1 – 1
4.11.2021, 22:00
Bayer 04 Leverkusen – Real Betis
4 – 0
4.11.2021, 22:00
Ferencváros TC – Celtic FC
2 – 3
25.11.2021, 19:45
Bayer 04 Leverkusen – Celtic FC
3 – 2
25.11.2021, 19:45
Real Betis – Ferencváros TC
2 – 0
9.12.2021, 22:00
Ferencváros TC – Bayer 04 Leverkusen
1 – 0
9.12.2021, 22:00
Celtic FC – Real Betis
3 – 2
Grupa H
| # | Echipa | M | V | E | I | GD | GP | Dif | P |
| 1 | West Ham United FC | 6 | 4 | 1 | 1 | 11 | 3 | 8 | 13 |
| 2 | GNK Dinamo Zagreb | 6 | 3 | 1 | 2 | 9 | 6 | 3 | 10 |
| 3 | Rapid Viena | 6 | 2 | 0 | 4 | 4 | 9 | -5 | 6 |
| 4 | KRC Genk | 6 | 1 | 2 | 3 | 4 | 10 | -6 | 5 |
Meciuri
16.09.2021, 19:45
GNK Dinamo Zagreb – West Ham United FC
0 – 2
16.09.2021, 19:45
Rapid Viena – KRC Genk
0 – 1
30.09.2021, 22:00
KRC Genk – GNK Dinamo Zagreb
0 – 3
30.09.2021, 22:00
West Ham United FC – Rapid Viena
2 – 0
21.10.2021, 19:45
Rapid Viena – GNK Dinamo Zagreb
2 – 1
21.10.2021, 22:00
West Ham United FC – KRC Genk
3 – 0
4.11.2021, 19:45
KRC Genk – West Ham United FC
2 – 2
4.11.2021, 22:00
GNK Dinamo Zagreb – Rapid Viena
3 – 1
25.11.2021, 19:45
GNK Dinamo Zagreb – KRC Genk
1 – 1
25.11.2021, 19:45
Rapid Viena – West Ham United FC
0 – 2
9.12.2021, 22:00
West Ham United FC – GNK Dinamo Zagreb
0 – 1
9.12.2021, 22:00
KRC Genk – Rapid Viena
0 – 1